Tanghetti Emil A
Center for Dermatology and Laser Surgery, Sacramento, California, USA.
Cutis. 2003 Feb;71(2):158-62.
The cause of the selective melanocyte destruction in vitiligo may be due to an autoimmune disorder. A series of 15 patients with vitiligo were treated with a topical immunomodulator, tacrolimus ointment 0.1%, twice daily for a minimum of 45 days. Thirteen patients (87%) experienced at least partial repigmentation, and 3 of those patients had greater than 75% repigmentation. Patients with the greatest treatment response likely benefited from concomitant natural sunlight exposure. Further studies investigating the safety and efficacy of tacrolimus ointment either as monotherapy or in combination with other therapeutic measures are warranted.
白癜风中黑素细胞选择性破坏的原因可能是自身免疫性疾病。对15例白癜风患者使用外用免疫调节剂0.1%他克莫司软膏进行治疗，每天两次，至少持续45天。13例患者（87%）至少出现了部分色素再生，其中3例患者色素再生超过75%。治疗反应最佳的患者可能受益于同时接受自然阳光照射。有必要进一步研究他克莫司软膏作为单一疗法或与其他治疗措施联合使用的安全性和有效性。
