他克莫司软膏促进儿童白癜风复色：57例病例回顾
Tacrolimus ointment promotes repigmentation of vitiligo in children: a review of 57 cases.
作者信息
Silverberg Nanette B, Lin Peggy, Travis Lisa, Farley-Li Jeanne, Mancini Anthony J, Wagner Annette M, Chamlin Sarah L, Paller Amy S
机构信息
Department of Dermatology, Division of Pediatric Dermatology, St Luke's-Roosevelt Hospital Center, New York, NY, USA.
出版信息
J Am Acad Dermatol. 2004 Nov;51(5):760-6. doi: 10.1016/j.jaad.2004.05.036.
BACKGROUND
Vitiligo is an autoimmune disorder characterized by loss of pigmentation. Phototherapy and application of topical corticosteroids are most commonly prescribed. However, these therapies are often not effective and use of corticosteroids on the face may lead to cutaneous atrophy, telangiectasia, and ocular complications.
OBJECTIVE
We sought to assess the efficacy of topical tacrolimus ointment in the treatment of pediatric vitiligo.
METHODS
A retrospective review was performed of 57 pediatric patients with vitiligo at two clinical sites. Patients were treated with tacrolimus ointment for at least 3 months. Clinical responses were documented during clinic visits, and by pretacrolimus and posttacrolimus photography.
RESULTS
At least partial response was noted to tacrolimus ointment on the head and neck in 89%, and on the trunk and extremities in 63% of patients. Facial vitiligo of the segmental type showed the best response rate. Two patients initially experienced burning on application.
CONCLUSIONS
Topical tacrolimus ointment is an effective alternative therapy for childhood vitiligo, particularly involving the head and neck.
背景
白癜风是一种以色素脱失为特征的自身免疫性疾病。光疗和外用糖皮质激素是最常用的治疗方法。然而，这些疗法往往无效，且在面部使用糖皮质激素可能会导致皮肤萎缩、毛细血管扩张和眼部并发症。
目的
我们旨在评估外用他克莫司软膏治疗儿童白癜风的疗效。
方法
对两个临床地点的57例儿童白癜风患者进行回顾性研究。患者接受他克莫司软膏治疗至少3个月。在门诊就诊时以及使用他克莫司之前和之后拍照记录临床反应。
结果
89%的患者头颈部使用他克莫司软膏后至少有部分反应，63%的患者躯干和四肢使用后有反应。节段型面部白癜风的反应率最高。两名患者最初用药时出现烧灼感。
结论
外用他克莫司软膏是儿童白癜风的一种有效替代疗法，尤其是对头颈部白癜风。
Zotero 插件