Benucci Maurizio, Gobbi Francesca Li, Del Rosso Angela, Cesaretti Simonetta, Niccoli Laura, Cantini Fabrizio
Rheumatology Unit ASL 10 Florence, Florence, Italy.
Scand J Rheumatol. 2003;32(1):42-5. doi: 10.1080/03009740310000391.
To evaluate the correlation between antinucleosome antibodies and disease activity in patients with systemic lupus erythematosus (SLE).
We evaluated antinucleosome antibodies (by ELISA) in 48 SLE patients. They were divided in 2 groups: positive (Group A, nr = 18) and negative (Group B, nr=30). The groups were evaluated for antinucleosome antibodies and for clinical, humoral parameters (hemoglobin, blood cell count, urinanalysis, ESR, ANA, anti-dsDNA, anticardiolipin antibodies, LAC), and ECLAM.
C3,C4, and hemoglobin were lower in Group A than (vs) group B (C3: 0.61 +/- 0.16 g/L vs 0.88 +/- 0.08 g/L, p < 0.001; C4: 0.086 +/- 0.03 g/L vs 0.18 +/- 0.07 g/L, p < 0.05; hemoglobin: 8.7 +/- 5.8 g/dL vs 12.7 +/- 1.44 g/dL; p < 0.02). ECLAM was higher in group A 7.56 +/- 2.19 vs group B 4.67 +/- 1.35 (p < 0.001). Urinary sediment was more altered in group A (88.8%) vs group B (33.3%; p < 0.001).
We found a correlation between antinucleosome antibodies and SLE disease activity as expressed by the higher ECLAM score in group A.
评估系统性红斑狼疮（SLE）患者抗核小体抗体与疾病活动度之间的相关性。
我们对48例SLE患者的抗核小体抗体进行了评估（采用酶联免疫吸附测定法）。他们被分为两组：阳性组（A组，n = 18）和阴性组（B组，n = 30）。对两组患者进行抗核小体抗体以及临床、体液参数（血红蛋白、血细胞计数、尿液分析、红细胞沉降率、抗核抗体、抗双链DNA抗体、抗心磷脂抗体、狼疮抗凝物）和子痫前期样综合征（ECLAM）的评估。
A组的C3、C4和血红蛋白水平低于B组（C3：0.61±0.16g/L对0.88±0.08g/L，p<0.001；C4：0.086±0.03g/L对0.18±0.07g/L，p<0.05；血红蛋白：8.7±5.8g/dL对12.7±1.44g/dL；p<0.02）。A组的ECLAM水平较高，为7.56±2.19，而B组为4.67±1.35（p<0.001）。A组尿沉渣改变更为明显（88.8%），而B组为33.3%（p<0.001）。
我们发现抗核小体抗体与SLE疾病活动度之间存在相关性，表现为A组的ECLAM评分较高。
