Kunisaki Yuya, Goto Hiroshi, Kitagawa Kikuo, Nagano Masanori
Department of Internal Medicine, Kyushu Kousei-Nenkin Hospital, Fukuoka.
Intern Med. 2003 Feb;42(2):203-7. doi: 10.2169/internalmedicine.42.203.
A 22-year-old woman with ulcerative colitis developed skin eruptions, liver dysfunction, and atypical lymphocytes in the peripheral blood two weeks after she started taking salazosulfapyridine (SASP). Skin eruptions and liver damage were severe. Drug-induced lymphocyte stimulation test (DLST) for SASP was positive. She was diagnosed as having SASP-induced hypersensitivity syndrome (HS). Corticosteroid therapy was needed to suppress these reactions. The transient elevation of HHV-6 IgG titer paralleled the symptoms, which indicated that these reactions were associated with the reactivation of HHV-6. We suggest that HHV-6 IgG titer is one of the modalities for the diagnosis and the prediction of the clinical course of HS.
一名22岁的溃疡性结肠炎女性患者在开始服用柳氮磺胺吡啶（SASP）两周后出现皮肤疹、肝功能障碍及外周血非典型淋巴细胞。皮肤疹和肝损伤严重。SASP的药物诱导淋巴细胞刺激试验（DLST）呈阳性。她被诊断为SASP诱导的超敏反应综合征（HS）。需要使用皮质类固醇疗法来抑制这些反应。HHV-6 IgG滴度的短暂升高与症状平行，这表明这些反应与HHV-6的重新激活有关。我们认为HHV-6 IgG滴度是诊断HS及预测其临床病程的方法之一。
