[柳氮磺胺吡啶诱发药物超敏反应综合征（DIHS）合并溃疡性结肠炎病例]

[Case of ulcerative colitis associated with drug-induced hypersensitivity syndrome (DIHS) by salazosulfapyridine].

作者信息

Nishimura Takashi, Obata Hirozumi, Fujino Hiroko, Sonoda Ayano, Sakamoto Kenichiro, Mizuno Chiemi, Mizuno Masayuki, Shima Toshihide, Nakajyo Shinobu, Fujiyama Yoshihide

机构信息

Department of Gastroenterology, Saiseikai Suita Hospital, and Department of Internal Medicine, Shiga University of Medical Science, Japan.

出版信息

Nihon Shokakibyo Gakkai Zasshi. 2007 Jan;104(1):36-41.

PMID:17230004

Abstract

We experienced a case of drug-induced hypersensitivity syndrome (DIHS) for salazosulfapyridine (SASP). After we started administration of SASP in a 26-year old man with ulcerative colitis (UC), he had symptoms resembling infectious mononucleosis, high fever, skin eruption, cervical lymphadenopathy, elevate white blood cell count with atypical lymphocyte, and liver dysfunction. We diagnosed the illness as drug-induced hypersensitivity syndrome (DIHS) due to SASP. We halted SASP and started administration of methylprednisolone and prednisolone but his condition deteriorated. We changed to administration of betamethasone and he recovered. In cases of DIHS accompanied by UC, we should administer drugs carefully and recognize serious complications.

摘要

我们遇到了一例因柳氮磺胺吡啶（SASP）导致的药物性超敏反应综合征（DIHS）。在一名患有溃疡性结肠炎（UC）的26岁男性开始服用SASP后，他出现了类似传染性单核细胞增多症的症状，包括高热、皮疹、颈部淋巴结肿大、白细胞计数升高伴非典型淋巴细胞以及肝功能障碍。我们将该疾病诊断为因SASP导致的药物性超敏反应综合征（DIHS）。我们停用了SASP，并开始给予甲泼尼龙和泼尼松龙，但他的病情恶化。我们改为给予倍他米松，他随后康复。在伴有UC的DIHS病例中，我们应谨慎用药并认识到严重并发症。