65岁及以上女性甲状腺激素使用与髋部骨折风险：一项病例对照研究。
Thyroid hormone use and the risk of hip fracture in women > or = 65 years: a case-control study.
作者信息
Van Den Eeden Stephen K, Barzilay Joshua I, Ettinger Bruce, Minkoff Jerome
机构信息
Division of Research, Kaiser Permanente, Northern California, Oakland, California 94612, USA.
出版信息
J Womens Health (Larchmt). 2003 Jan-Feb;12(1):27-31. doi: 10.1089/154099903321154112.
BACKGROUND
There is controversy about whether thyroid hormone therapy may lead to osteoporosis, and less is known about the clinically more important end point of whether its use increases fracture risk.
METHODS
We used a case-control study to examine the association between thyroid hormone use and hip fractures among older women in a large managed care organization in Northern California. The subjects were 501 women > or =65 years of age who were hospitalized for hip fractures and 533 age-matched controls without hip fractures.
RESULTS
No difference in the ever use or duration of use of exogenous thyroid hormone was found between cases and controls (odds ratio [OR] 1.1, 95% confidence interval [CI] 0.8,1.6). Hip fracture was associated with evidence of visual impairment, prior use of steroids, and number of falls.
CONCLUSIONS
In women > or =65 years, an independent effect of thyroid hormone use on the risk of hip fracture was not found. This finding is reassuring, given the large number of women on thyroid hormone therapy today.
背景
甲状腺激素治疗是否会导致骨质疏松存在争议，而关于其使用是否会增加骨折风险这一临床上更重要的终点，人们了解得更少。
方法
我们采用病例对照研究，以检验北加利福尼亚一个大型管理式医疗组织中老年女性甲状腺激素使用与髋部骨折之间的关联。研究对象为501名年龄≥65岁因髋部骨折住院的女性以及533名年龄匹配的无髋部骨折的对照者。
结果
病例组和对照组在外源性甲状腺激素的既往使用情况或使用时长方面未发现差异（优势比[OR]为1.1，95%置信区间[CI]为0.8,1.6）。髋部骨折与视力损害证据、既往使用类固醇以及跌倒次数相关。
结论
在年龄≥65岁的女性中，未发现甲状腺激素使用对髋部骨折风险有独立影响。鉴于如今接受甲状腺激素治疗的女性数量众多，这一发现令人安心。
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