Grisso J A, Kelsey J L, Strom B L, Chiu G Y, Maislin G, O'Brien L A, Hoffman S, Kaplan F
Clinical Epidemiology Unit, School of Medicine, University of Pennsylvania, Philadelphia 19104-6095.
N Engl J Med. 1991 May 9;324(19):1326-31. doi: 10.1056/NEJM199105093241905.
Although even in the elderly most falls are not associated with fractures, over 90 percent of hip fractures are the result of a fall. Few studies have assessed whether the risk factors for falls are also important risk factors for hip fracture.
To examine the importance of risk factors for falls in the epidemiology of hip fracture, we performed a case-control study of 174 women (median age, 80 years) admitted with a first hip fracture to 1 of 30 hospitals in New York and Philadelphia. Controls, matched to the case patients according to age and hospital, were selected from general surgical and orthopedic surgical hospital services. Information was obtained by direct interview.
As measured by the odds ratio, increased risks for hip fracture were associated with lower-limb dysfunction (odds ratio = 1.7; 95 percent confidence interval, 1.1 to 2.8), visual impairment (odds ratio = 5.1; 95 percent confidence interval, 1.9 to 13.9), previous stroke (odds ratio = 2.0; 95 percent confidence interval, 1.0 to 4.0), Parkinson's disease (odds ratio = 9.4; 95 percent confidence interval, 1.2 to 76.1), and use of long-acting barbiturates (odds ratio = 5.2; 95 percent confidence interval, 0.6 to 45.0). Of the controls, 44 (25 percent) had had a recent fall. The case patients were more likely than these controls to have fallen from a standing height or higher (odds ratio = 2.4; 95 percent confidence interval, 1.0 to 5.7). Of those with hip fracture the younger patients (less than 75 years old) were more likely than the older ones (greater than or equal to 75 years old) to have fallen on a hard surface (odds ratio = 1.9; 95 percent confidence interval, 1.04 to 3.7).
A number of factors that have been identified as risk factors for falls are also associated with hip fracture, including lower-limb dysfunction, neurologic conditions, barbiturate use, and visual impairment. Given the prevalence of these problems among the elderly, who are at highest risk, programs to prevent hip fracture should include measures to prevent falls in addition to measures to slow bone loss.
尽管即使在老年人中,大多数跌倒也与骨折无关,但超过90%的髋部骨折是跌倒所致。很少有研究评估跌倒的危险因素是否也是髋部骨折的重要危险因素。
为了研究跌倒危险因素在髋部骨折流行病学中的重要性,我们对纽约和费城30家医院中的1家收治的174例首次发生髋部骨折的女性患者(中位年龄80岁)进行了一项病例对照研究。根据年龄和医院与病例患者匹配的对照,从普通外科和整形外科医院服务中选取。通过直接访谈获取信息。
以比值比衡量,髋部骨折风险增加与下肢功能障碍(比值比=1.7;95%置信区间,1.1至2.8)、视力障碍(比值比=5.1;95%置信区间,1.9至13.9)、既往中风(比值比=2.0;95%置信区间,1.0至4.0)、帕金森病(比值比=9.4;95%置信区间,1.2至76.1)以及使用长效巴比妥类药物(比值比=5.2;95%置信区间,0.6至45.0)相关。在对照组中,44例(25%)近期有过跌倒。病例患者比这些对照更有可能从站立高度或更高处跌倒(比值比=2.4;95%置信区间,1.0至5.7)。在髋部骨折患者中,较年轻患者(小于75岁)比年长患者(大于或等于75岁)更有可能在硬地面跌倒(比值比=1.9;95%置信区间,1.04至3.7)。
一些已被确定为跌倒危险因素的因素也与髋部骨折相关,包括下肢功能障碍、神经系统疾病、巴比妥类药物使用和视力障碍。鉴于这些问题在高危老年人中普遍存在,预防髋部骨折的项目除了采取减缓骨质流失的措施外,还应包括预防跌倒的措施。