Traumann K J
Med Klin. 1976 Mar 12;71(11):465-8.
102 patients suffering from peripheral occlusive vascular disease were treated with Pentoxifylline (Trental) parenterally (i.v. infusions) and orally (dragees). Surprisingly good therapeutic response was obtained not only in patients stage II but also stage III (after Fontaine), in total 84% of the patients showing improvement. These favourable results can only be explained by increase of nutritious circulation indicating an improvement of blood-flow-properties in the microvasculature. The observed particular efficacy of Pentoxifylline necessitates a more differentiated valuation of the systemic (intravenous) administration of vasoactive drugs all the more so as the majority of patients with occlusive vascular disease are accessible to conservative treatment only.
102例外周闭塞性血管疾病患者接受了己酮可可碱（曲克芦丁）的肠外（静脉输注）和口服（糖衣丸）治疗。不仅II期患者，而且III期（根据Fontaine分期）患者都获得了令人惊讶的良好治疗反应，总共有84%的患者病情有所改善。这些良好结果只能通过营养循环的增加来解释，这表明微血管系统中血流特性得到了改善。己酮可可碱所观察到的特殊疗效使得有必要对血管活性药物的全身（静脉）给药进行更细致的评估，尤其是因为大多数闭塞性血管疾病患者只能接受保守治疗。
