Keul J, Deus B, Kindermann W
Med Klin. 1976 Mar 19;71(12):497-503.
10 normal persons (age: x=22 years) and 15 weight lifters (age: x=27 years) were studied before and three months after taking Nandrolone danoate (ND). Strength exercises, hear rate during ergometer work, physical working capacity and certain biochemical variables were measured in the experimental group, as well as in a controll group of 7 weight lifters. Six weight lifters in the experimental group who had been taking ND for at least 3 years were also studied to determine whether there were any deleterious effects on their health. In addition, 75 athletes who had been taking anabolic steroids were investigated to determine the possible effects. It was found that: 1. In spite of an 7% increase in performance, the maximal heart rate was not higher when the subjects took ND. During submaximal work loads the heart rate (p less than 0.025) and the blood lactate level (p less than 0.05) were lower. During physical work, there was essentially no effect of ND on glucose or total lipids in serum. 2. The results from the three-months study, from the weight lifters taking ND for 3 years, as well as from 26 of the 57 athletes who had been taking ND showed no evidence of a deleterious effect of ND (based on 26 biochemical measurements). It would appear, therefore, that the general suggestion of a detrimental effect of anabolic hormones is not justified. 3. Damages or functional disturbances were found in 31 athletes and 3 weight lifters of the experimental group after oral application of anabolic alkyl-steroids. After a period of time without alkyl-steroid administration, all investigated biochemical parameters returned to normal levels; thus it appears that the aforementioned pathological findings are reversible changes in liver function.
对10名正常人（年龄：x = 22岁）和15名举重运动员（年龄：x = 27岁）在服用癸酸诺龙（ND）之前及之后三个月进行了研究。对实验组以及由7名举重运动员组成的对照组测量了力量训练、测力计运动时的心率、身体工作能力和某些生化变量。还对实验组中6名服用ND至少3年的举重运动员进行了研究，以确定其对健康是否有任何有害影响。此外，对75名一直在服用合成代谢类固醇的运动员进行了调查，以确定可能产生的影响。结果发现：1. 尽管服用ND后运动能力提高了7%，但受试者的最大心率并未升高。在次最大工作负荷下，心率（p < 0.025）和血乳酸水平（p < 0.05）较低。在体力工作期间，ND对血清中的葡萄糖或总脂质基本没有影响。2. 为期三个月的研究结果、服用ND 3年的举重运动员的结果以及57名服用ND的运动员中的26名的结果均未显示ND有有害影响的证据（基于26项生化测量）。因此，合成代谢激素具有有害影响的普遍观点似乎没有依据。3. 在实验组的31名运动员和3名举重运动员口服合成代谢烷基类固醇后发现了损伤或功能障碍。在一段时间不服用烷基类固醇后，所有调查的生化参数均恢复到正常水平；因此，上述病理发现似乎是肝功能的可逆变化。
