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HIF hydroxylation and the mammalian oxygen-sensing pathway.

作者信息

Safran Michal, Kaelin William G

机构信息

Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

出版信息

J Clin Invest. 2003 Mar;111(6):779-83. doi: 10.1172/JCI18181.

Abstract
摘要

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本文引用的文献

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Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13459-64. doi: 10.1073/pnas.192342099. Epub 2002 Sep 26.
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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
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Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
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