HIF hydroxylation and the mammalian oxygen-sensing pathway.
作者信息
Safran Michal, Kaelin William G
机构信息
Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
出版信息
J Clin Invest. 2003 Mar;111(6):779-83. doi: 10.1172/JCI18181.
Abstract
摘要
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本文引用的文献
1
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.作用于缺氧诱导因子的哺乳动物脯氨酰羟化酶的生化纯化及药理抑制
Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13459-64. doi: 10.1073/pnas.192342099. Epub 2002 Sep 26.
2
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma.VHL底物结合和HIF1-α对肾细胞癌中VHL缺失表型的作用。
Cancer Cell. 2002 Apr;1(3):247-55. doi: 10.1016/s1535-6108(02)00044-2.
3
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.缺氧诱导因子的抑制对于希佩尔-林道蛋白的肿瘤抑制作用是必要的。
Cancer Cell. 2002 Apr;1(3):237-46. doi: 10.1016/s1535-6108(02)00043-0.
4
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.FIH-1是一种天冬酰胺酰羟化酶，可调节缺氧诱导因子的转录活性。
Genes Dev. 2002 Jun 15;16(12):1466-71. doi: 10.1101/gad.991402.
5
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.pVHL识别缺氧诱导因子-1α（HIF-1α）中羟脯氨酸的结构基础。
Nature. 2002 Jun 27;417(6892):975-8. doi: 10.1038/nature00767. Epub 2002 Jun 5.
6
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.缺氧诱导因子（HIF）天冬酰胺羟化酶与缺氧诱导因子抑制因子（FIH）相同，且与铜蛋白结构家族相关。
J Biol Chem. 2002 Jul 19;277(29):26351-5. doi: 10.1074/jbc.C200273200. Epub 2002 May 31.
7
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.缺氧诱导因子-1α（HIF-1α）-泛素连接酶E3（pVHL）复合物的结构：信号传导中的羟脯氨酸识别
Science. 2002 Jun 7;296(5574):1886-9. doi: 10.1126/science.1073440. Epub 2002 May 9.
8
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.缺氧诱导因子-1α募集CBP/p300的结构基础。
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5367-72. doi: 10.1073/pnas.082117899.
9
Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response.细胞缺氧反应中Hif-1α/CBP识别的结构基础。
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5271-6. doi: 10.1073/pnas.082121399.
10
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.缺氧诱导因子反式激活结构域的天冬酰胺羟基化——一种缺氧开关
Science. 2002 Feb 1;295(5556):858-61. doi: 10.1126/science.1068592.
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