Ouyang Fengxiu, Shen Fumin, Jiang Feng, Hu Haiqin, Pan Mingming
Department of Child and Adolescent Health, School of Public Health, Fudan University, Shanghai 200032, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2002 Nov;36(6):378-81.
To identify risk factors for gestational diabetes mellitus (GDM) in women and to study the contribution of family history of type-2 diabetes to the risk for DDM.
A case-control study was performed in 85 women with GDM and 177 cases controls. Univariate and multivariate logistic regression and log-linear model were used to identify risk factors of GDM.
Multivariate logistic regression showed that obesity before pregnancy, family history of type-2 diabetes, birth weight of pregnant women, age, fasting plasma level of triglyceride, physical inactivity, etc. all were risk factors for GDM. Analysis with log-linear model showed that parents' (father's or mother's) history of type-2 diabetes associated with GDM, with P-values of 0.012 and 0.017, respectively. Prevalence of diabetes in the mothers of proband with GDM was 9.41%, as compared with that in the fathers of proband with GDM 8.24%, with no statistical significance.
Obesity before gestation, family history of type-2 diabetes, low birth weight of mother, age, increased fasting plasma level of triglyceride, as well as parents' history of type-2 diabetes, all were risk factors for GDM. Physical exercise was found to be a protective factor for GDM. Mother's history of type-2 diabetes did not differ from father's in contributing to the onset of GDM in their offspring.
确定女性妊娠糖尿病（GDM）的危险因素，并研究2型糖尿病家族史对GDM风险的影响。
对85例GDM患者和177例对照进行病例对照研究。采用单因素和多因素逻辑回归以及对数线性模型来确定GDM的危险因素。
多因素逻辑回归显示，孕前肥胖、2型糖尿病家族史、孕妇出生体重、年龄、空腹血浆甘油三酯水平、缺乏体育活动等均为GDM的危险因素。对数线性模型分析显示，父母（父亲或母亲）的2型糖尿病病史与GDM相关，P值分别为0.012和0.017。GDM先证者母亲的糖尿病患病率为9.41%，GDM先证者父亲的糖尿病患病率为8.24%，差异无统计学意义。
孕前肥胖、2型糖尿病家族史、母亲低出生体重、年龄、空腹血浆甘油三酯水平升高以及父母的2型糖尿病病史均为GDM的危险因素。体育锻炼是GDM的保护因素。母亲的2型糖尿病病史在其后代GDM发病中的作用与父亲的无差异。
