Bravo Emmanuel L
Department of Nephrology and Hypertension, Cleveland Clinic Foundation, 9500 Euclid Avenue - Desk A51, OH 44195, USA.
Curr Hypertens Rep. 2003 Apr;5(2):122-5. doi: 10.1007/s11906-003-0068-z.
Recent preclinical and clinical studies indicate that aldosterone, independent of angiotensin II and elevated blood pressure, may play a role in health and disease. In addition to its role in fluid and electrolyte balance and circulatory homeostasis, more recent studies have identified aldosterone as a critical mediator of vascular damage. In animal studies, aldosterone is implicated in cardiac and vascular fibrosis, renal disease, and cerebrovascular damage. These lesions are prevented by specific aldosterone receptor blockade. In clinical studies, aldosterone receptor antagonism is associated with decreased hospitalization, symptomatology, and mortality, and improvement of endothelial dysfunction in patients with chronic heart failure. A better understanding of aldosterone's actions in nonepithelial tissues should pave the way to better protection of organs at risk such as the kidneys, heart, and brain.
近期的临床前和临床研究表明，醛固酮独立于血管紧张素II且不依赖于血压升高，可能在健康和疾病中发挥作用。除了在体液和电解质平衡以及循环稳态中发挥作用外，最近的研究已将醛固酮确定为血管损伤的关键介质。在动物研究中，醛固酮与心脏和血管纤维化、肾脏疾病以及脑血管损伤有关。这些病变可通过特异性醛固酮受体阻断来预防。在临床研究中，醛固酮受体拮抗作用与慢性心力衰竭患者住院率降低、症状减轻、死亡率降低以及内皮功能障碍改善有关。更好地了解醛固酮在非上皮组织中的作用应为更好地保护肾脏、心脏和大脑等易损器官铺平道路。
