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[社论:粒细胞存活时间的差异(作者译)]

[Editorial: Discrepancies in granulocyte survival time (author's transl)].

作者信息

Najean Y

出版信息

Nouv Rev Fr Hematol. 1975 Jan-Feb;15(1):5-12.

PMID:126424
Abstract

Important discrepancies between the renewal rate of mature granulocytes measured by in vitro labelling with DF 32P and with sodium chromate 51Cr are observed. The possible explanations are reviewed: errors made in the drawing of the experimental curve of the radioactivity disappearance; labelling of long-living lymphocytes with chromium; elution of 32P; toxicity of DFP for the tagged cells. If the renewal-rate measured by using 51Cr is the real one, as it seems to be, currently accepted models of granulopoiesis will need reappraisal.

摘要

观察到用³²P-DF体外标记法和⁵¹Cr-铬酸钠法测定的成熟粒细胞更新率之间存在重要差异。对可能的解释进行了综述:放射性消失实验曲线绘制中的误差;铬对长寿淋巴细胞的标记;³²P的洗脱;DFP对标记细胞的毒性。如果用⁵¹Cr测量的更新率是真实的,就像看起来的那样,那么目前公认的粒细胞生成模型将需要重新评估。

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