Dresch C, Faille A, Rain J D, Najean Y
Nouv Rev Fr Hematol. 1975 Jan-Feb;15(1):31-55.
Several methods measuring the granulocyte production have been compared in normal subjects, hypoplastic granulopenia, chronic leucopenia and acute leukemia: the granulocyte turnover-rate after injection of in vitro 51Cr labelled autologous granulocytes, the efficiency of 75Se-selenothionine in vivo labelling, the flow-out of the myelocyte compartment after in vitro flash-labelling with 3H-thymidine. The two first methods are correlated and measure the global effective production of granulocytes. The third method is a fractional measure of the bone marrow production and is not correlated with the former ones. The ratio between the granulocyte turnover-rate and the flow-out of the bone marrow proliferative pool is a measure of the bone marrow cellularity. Discrepancies between this measure and the granulocyte turnover-rate has been found only in leukaemic patients.
在正常受试者、再生障碍性粒细胞减少症患者、慢性白细胞减少症患者和急性白血病患者中，对几种测量粒细胞生成的方法进行了比较：注射体外51Cr标记的自体粒细胞后的粒细胞周转率、75Se-硒代蛋氨酸体内标记的效率、用3H-胸腺嘧啶核苷体外快速标记后骨髓细胞区室的流出率。前两种方法相互关联，可测量粒细胞的整体有效生成。第三种方法是对骨髓生成的部分测量，与前两种方法不相关。粒细胞周转率与骨髓增殖池流出率之间的比率是骨髓细胞密度的一种测量方法。仅在白血病患者中发现了这种测量方法与粒细胞周转率之间的差异。
