Duhamel G, Gorin N C, Najaman A, André R
Nouv Rev Fr Hematol. 1975 Jan-Feb;15(1):99-105.
Myelofibrosis is observed in 1/5 of the cases of C.M.L. It consists of reticulin fibers with few collagen and no osteosclerosis. It involves signs which usually indicate the extension of the myelosis to other organs and other types of cells: hepatosplenomegaly, erythroblastosis, thrombocytemia. Its prognosis is always bad. In one third of the cases, myelofibrosis develops early, and in two third it is late. Chimiotherapy is not responsible for it. These forms of C.M.L. with myelofibrosis appear as a special type of myeloproliferative disorder apart from the true C.M.L. and the true osteomyelofibrosis.
骨髓纤维化见于1/5的慢性髓性白血病病例中。它由网状纤维组成，胶原很少，无骨硬化。它涉及一些通常表明髓细胞增生扩展至其他器官和其他类型细胞的体征：肝脾肿大、成红细胞增多、血小板增多。其预后总是很差。在1/3的病例中，骨髓纤维化早期发生，2/3为晚期。化疗与此无关。这些伴有骨髓纤维化的慢性髓性白血病形式表现为一种特殊类型的骨髓增殖性疾病，有别于真正的慢性髓性白血病和真性骨髓纤维化。
