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各种吸附剂对凝血因子的影响(作者译)

[Effects of various adsorbants on coagulation factors (author's transl)].

作者信息

Soulier J P, Prou-Wartelle O

出版信息

Nouv Rev Fr Hematol. 1975 Mar-Apr;15(2):195-211.

PMID:126430
Abstract

Adsorption of clotting factors by various adsorbants is studied (tricalcium phosphate, baryum sulfate or carbonate or citrate, calcium oxalate, aluminium hydroxyde and several silicate such as: kaolin, celite, bentonite, attapulgite, beidellite, asbestos). The main properties of each adsorbant are listed as well as several applications such as: selective adsorption of fibrinogen, separation between fibrinogen and factor VIII, separation of factor II from the other components of the prothrombin complex. Activation of factors XII and XI by the various silicates, as well as the activation of factor V by attapulgite are studied. Finally, the action of such adsorbants on the fibrinolytic system is summarized.

摘要

研究了各种吸附剂(磷酸三钙、硫酸钡或碳酸钡或柠檬酸盐、草酸钙、氢氧化铝以及几种硅酸盐,如高岭土、硅藻土、膨润土、凹凸棒石、贝得石、石棉)对凝血因子的吸附作用。列出了每种吸附剂的主要特性以及几种应用,如:纤维蛋白原的选择性吸附、纤维蛋白原与因子VIII的分离、凝血酶原复合物中因子II与其他成分的分离。研究了各种硅酸盐对因子XII和XI的激活作用,以及凹凸棒石对因子V的激活作用。最后,总结了此类吸附剂对纤溶系统的作用。

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