低剂量抑肽酶对用硅藻土和高岭土激活的凝血时间的影响。

Effects of low doses of aprotinin on clotting times activated with celite and kaolin.

作者信息

Farooqi N, De Hert S, Vlaeminck R, De Bakker A, Govaerts E, Vermeyen K

机构信息

Department of Anesthesia, University Hospital Antwerp, Edegem, Belgium.

出版信息

Acta Anaesthesiol Belg. 1993;44(3):87-92.

PMID:7508668

Abstract

The effects of aprotinin (2 x 10(6) and 4 x 10(6) PIU Iniprol) on the activated clotting time (ACT) with both celite- and kaolin-activated tubes were investigated in 52 patients, scheduled for elective coronary artery bypass grafting. Two whole blood samples (2 ml sample volume) were tested simultaneously with Hemochron automated timing systems at different intervals before, during and after cardiopulmonary bypass. At none of the times of measurement there was a difference in ACT measured with celite or with kaolin as coagulation activator. It is concluded that when aprotinin is used in this low dose regimen, celite- and kaolin-activated tubes are equally reliable for monitoring ACT.

摘要

在52例计划进行择期冠状动脉搭桥术的患者中，研究了抑肽酶（2×10⁶和4×10⁶ 抑肽酶国际单位）对硅藻土激活管和高岭土激活管激活凝血时间（ACT）的影响。在体外循环前、期间和之后的不同时间间隔，使用Hemochron自动计时系统同时检测两份全血样本（样本体积2ml）。在任何测量时间，以硅藻土或高岭土作为凝血激活剂测得的ACT均无差异。得出的结论是，当以这种低剂量方案使用抑肽酶时，硅藻土激活管和高岭土激活管在监测ACT方面同样可靠。