Lovejoy Jennifer C
Women's Nutrition Research Program, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
Curr Diab Rep. 2002 Oct;2(5):435-40. doi: 10.1007/s11892-002-0098-y.
Dietary fat has been implicated in the development of insulin resistance in both animals and humans. Most, although not all, studies suggest that higher levels of total fat in the diet result in greater whole-body insulin resistance. Although, in practice, obesity may complicate the relationship between fat intake and insulin resistance, clinical trials demonstrate that high levels of dietary fat can impair insulin sensitivity independent of body weight changes. In addition, it appears that different types of fat have different effects on insulin action. Saturated and certain monounsaturated fats have been implicated in causing insulin resistance, whereas polyunsaturated and omega-3 fatty acids largely do not appear to have adverse effects on insulin action. Given the importance of insulin resistance in the development of diabetes and heart disease, establishing appropriate levels of fat in the diet is an important clinical goal.
膳食脂肪已被认为与动物和人类胰岛素抵抗的发展有关。大多数（尽管不是全部）研究表明，饮食中总脂肪含量较高会导致更大程度的全身胰岛素抵抗。虽然在实际情况中，肥胖可能会使脂肪摄入与胰岛素抵抗之间的关系变得复杂，但临床试验表明，高膳食脂肪水平可独立于体重变化而损害胰岛素敏感性。此外，不同类型的脂肪对胰岛素作用似乎有不同影响。饱和脂肪和某些单不饱和脂肪被认为会导致胰岛素抵抗，而多不饱和脂肪酸和ω-3脂肪酸在很大程度上似乎对胰岛素作用没有不良影响。鉴于胰岛素抵抗在糖尿病和心脏病发展中的重要性，确定饮食中适当的脂肪水平是一个重要的临床目标。
