Jude E B, Boulton A J
Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
Curr Diab Rep. 2001 Dec;1(3):228-32. doi: 10.1007/s11892-001-0038-2.
Charcot neuroarthropathy is not uncommon in diabetic patients with peripheral neuropathy. Often, the condition is misdiagnosed for cellulitis or osteomyelitis and treatment is delayed. A high index of suspicion is required in these patients to initiate appropriate treatment early. This article covers the pathogeneses of this condition and briefly describes the recent studies performed to understand the underlying etiopathogenetic factors of this devastating condition. Lastly, it mentions the recently completed multicenter trial using bisphosphonates in diabetic Charcot neuroarthropathy.
夏科氏神经关节病在患有周围神经病变的糖尿病患者中并不罕见。这种病症常常被误诊为蜂窝织炎或骨髓炎,从而导致治疗延误。对于这些患者,需要高度怀疑以尽早开始适当治疗。本文涵盖了这种病症的发病机制,并简要描述了为了解这种破坏性病症的潜在病因学因素而进行的最新研究。最后,它提到了最近完成的一项在糖尿病性夏科氏神经关节病中使用双膦酸盐的多中心试验。