Faden A, Golbus M, Spire J P
Obstet Gynecol. 1976 May;47(5):607-8.
Electroencephalograms were obtained on 43 patients undergoing therapeutic second trimester abortion using intraamniotic prostaglandin F2alpha. Recordings were made before and 4 hours after prostaglandin administration, as well as 4 hours after the abortion. At 4 hours after prostaglandin administration, 30% of the women had abnormal tracings, while 50% of the women had abnormal recordings 4 hours postabortion. Although the changes consisted primarily of mild generalized or lateralized slowing, 4 patients developed paroxysmal activity not initially present. This finding would seem to suggest a potential relationship between PGF2alpha administration and clinical seizures.
对43名在妊娠中期使用羊膜腔内前列腺素F2α进行治疗性流产的患者进行了脑电图检查。在给予前列腺素之前、给药后4小时以及流产后4小时进行记录。给予前列腺素后4小时，30%的女性脑电图有异常，而流产后4小时，50%的女性记录异常。虽然这些变化主要表现为轻度的全身性或局限性慢波，但有4名患者出现了最初不存在的阵发性活动。这一发现似乎表明给予PGF2α与临床癫痫发作之间可能存在关联。
