白细胞介素-10，一种炎性/抑制性细胞因子，但并非总是如此。

IL-10, an inflammatory/inhibitory cytokine, but not always.

作者信息

Conti Pio, Kempuraj Duraisamy, Kandere Kristiana, Di Gioacchino Mario, Barbacane Renato C, Castellani Maria L, Felaco Mario, Boucher William, Letourneau Richard, Theoharides Theoharis C

机构信息

Immunology Division, University of Chieti, School of Medicine, Chieti, Italy.

出版信息

Immunol Lett. 2003 Apr 3;86(2):123-9. doi: 10.1016/s0165-2478(03)00002-6.

DOI:10.1016/s0165-2478(03)00002-6

PMID:12644313

Abstract

IL-10 has been previously called cytokine synthesis inhibiting factor, produced mostly by Th2 cells, macrophages and CD8+ cell clones. IL-10 is capable of inhibiting the synthesis of several cytokines from different cells, antigen or mitogen activated. IL-10 exerts its inhibition at the mRNA transcriptional and translational level. In addition, IL-10 is a co-stimulatory cytokine on activated T cells. For example, IL-10 inhibits NK cell activity, the production of Th1 cytokines, cytokines generated by peripheral blood mononuclear cells, and macrophage activity. On the other hand, IL-10 exerts immunostimulatory effects on B cells, cytotoxic T cell development and thymocytes. In mast cells derived from CD4+/CD133+ cells, IL-10 inhibits IL-6 and TNFalpha, and prostaglandin E(1) and E(2) induced by IL-6. Here, we report for the first time that IL-10 fails to inhibit tryptase and IL-6 from human mast cell-1 (HMC-1) and human umbilical cord blood-derived mast cells.

摘要

白细胞介素-10（IL-10）以前被称为细胞因子合成抑制因子，主要由Th2细胞、巨噬细胞和CD8 +细胞克隆产生。IL-10能够抑制来自不同细胞、抗原或丝裂原激活的多种细胞因子的合成。IL-10在mRNA转录和翻译水平发挥其抑制作用。此外，IL-10是活化T细胞上的共刺激细胞因子。例如，IL-10抑制自然杀伤细胞（NK细胞）活性、Th1细胞因子的产生、外周血单核细胞产生的细胞因子以及巨噬细胞活性。另一方面，IL-10对B细胞、细胞毒性T细胞发育和胸腺细胞发挥免疫刺激作用。在源自CD4 + / CD133 +细胞的肥大细胞中，IL-10抑制IL-6和肿瘤坏死因子α（TNFα），以及由IL-6诱导的前列腺素E（1）和E（2）。在此，我们首次报道IL-10不能抑制人肥大细胞-1（HMC-1）和人脐带血来源的肥大细胞中的类胰蛋白酶和IL-6。