Šimičić Petra, Batović Margarita, Stojanović Marković Anita, Židovec-Lepej Snjezana
Department of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, Vinogradska cesta 29, 10 000 Zagreb, Croatia.
Department of Clinical Microbiology and Hospital Infections, Dubrava University Hospital, Avenija Gojka Šuška 6, 10 000 Zagreb, Croatia.
Viruses. 2024 Apr 4;16(4):564. doi: 10.3390/v16040564.
The disruption of antiviral sensors and the evasion of immune defences by various tactics are hallmarks of EBV infection. One of the EBV latent gene products, LMP1, was shown to induce the activation of signalling pathways, such as NF-κB, MAPK (JNK, ERK1/2, p38), JAK/STAT and PI3K/Akt, via three subdomains of its C-terminal domain, regulating the expression of several cytokines responsible for modulation of the immune response and therefore promoting viral persistence. The aim of this review is to summarise the current knowledge on the EBV-mediated induction of immunomodulatory molecules by the activation of signal transduction pathways with a particular focus on LMP1-mediated mechanisms. A more detailed understanding of the cytokine biology molecular landscape in EBV infections could contribute to the more complete understanding of diseases associated with this virus.
抗病毒传感器的破坏以及通过各种策略逃避免疫防御是EBV感染的标志。EBV潜伏基因产物之一LMP1已被证明可通过其C末端结构域的三个亚结构域诱导信号通路的激活，如NF-κB、MAPK（JNK、ERK1/2、p38）、JAK/STAT和PI3K/Akt，调节几种负责调节免疫反应的细胞因子的表达，从而促进病毒持续存在。本综述的目的是总结当前关于EBV通过激活信号转导通路介导免疫调节分子诱导的知识，特别关注LMP1介导的机制。更详细地了解EBV感染中细胞因子生物学的分子格局可能有助于更全面地了解与该病毒相关的疾病。
