Jo Yukihiko, Matsumoto Takayuki, Yada Shinichiro, Nakamura Shotaro, Yao Takashi, Hotokezaka Masayuki, Mibu Ryuichi, Iida Mitsuo
Department of Medicine and Clinical Science , Graduate School of Medical Sciences, Kyushu University, Kyushu University Hospital, Maidashi 3-1-1, Higashi-ku Fukuoka 812-8582, Japan.
Dig Dis Sci. 2003 Jan;48(1):99-108. doi: 10.1023/a:1021742616794.
Patients with ulcerative colitis (UC) have a less frequent prior history of appendectomy than the general population. The aim of the present investigation was to elucidate histological and immunological characteristics of the appendix in UC and to assess the effect of appendectomy on the disease. Nine subjects with mildly active UC were treated by surgical appendectomy. In four subjects, the histological findings of the appendix were compatible with ulcerative appendicitis. CD3+CD4+CD25+, CD3+CD4+CD45RO+, and CD3+CD8+CD45RO+ appendiceal mononuclear cells were significantly higher in UC than in acute appendicitis and in normal appendix. There was a trend towards higher mRNA transcripts of IFN-gamma in the appendix of UC than those in other two groups. Clinical activity index decreased significantly four weeks after the appendectomy, although the effect was transient. The appendix is a site of involvement in UC, where mononuclear cells are presumed to be at a state of basal activation.
溃疡性结肠炎（UC）患者既往阑尾切除术的发生率低于普通人群。本研究的目的是阐明UC患者阑尾的组织学和免疫学特征，并评估阑尾切除术对该疾病的影响。9例轻度活动性UC患者接受了手术阑尾切除术。在4例患者中，阑尾的组织学表现符合溃疡性阑尾炎。UC患者阑尾中CD3+CD4+CD25+、CD3+CD4+CD45RO+和CD3+CD8+CD45RO+阑尾单个核细胞显著高于急性阑尾炎患者和正常阑尾患者。UC患者阑尾中IFN-γ的mRNA转录本有高于其他两组的趋势。阑尾切除术后4周临床活动指数显著下降，尽管这种效果是短暂的。阑尾是UC的受累部位，推测其中的单个核细胞处于基础激活状态。
