Klein-Schwartz Wendy, Shepherd J Greene, Gorman Susan, Dahl Brad
Maryland Poison Center, Department of Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, USA.
J Toxicol Clin Toxicol. 2003;41(1):11-5. doi: 10.1081/clt-120018265.
Gabapentin is an anticonvulsant that is being used for an increasing number of off-label indications. The purpose of this study is to document the clinical manifestations and outcomes of gabapentin exposures reported to poison centers.
A multicenter prospective observational study of all gabapentin exposures reported to three poisoncenters was conducted between 4/1/98 and 4/1/2000. Cases involving gabapentin only were evaluated.
There were 20 cases with gabapentin as the sole substance in doses ranging from 50 mg to 35 g. Ten of the 20 cases involved children and adolescents. Clinical effects developed early and resolved within 10 hours in most patients. Seven cases were managed in the home with only observation. Four of these patients remained asymptomatic. Effects reported in the three symptomatic patients were drowsiness (3) and ataxia (1). Thirteen patients were managed in a health care facility. Nine were symptomatic with reported effects of drowsiness (6), dizziness (3), nausea/vomiting (2), tachycardia (2), and hypotension (2). None of the patients were admitted for medical care.
In this cases series, gabapentin exposures caused no or minimal toxicity.
加巴喷丁是一种抗惊厥药，正被越来越多地用于治疗多种未标明的适应症。本研究的目的是记录向中毒控制中心报告的加巴喷丁暴露的临床表现和结果。
在1998年4月1日至2000年4月1日期间，对向三个中毒控制中心报告的所有加巴喷丁暴露进行了一项多中心前瞻性观察研究。仅对涉及加巴喷丁的病例进行评估。
有20例仅服用加巴喷丁的病例，剂量范围为50毫克至35克。20例中有10例涉及儿童和青少年。大多数患者的临床症状出现较早，并在10小时内缓解。7例患者在家中仅通过观察进行处理。其中4例患者无症状。3例有症状患者报告的症状为嗜睡（3例）和共济失调（1例）。13例患者在医疗机构接受处理。9例有症状，报告的症状为嗜睡（6例）、头晕（3例）、恶心/呕吐（2例）、心动过速（2例）和低血压（2例）。没有患者因医疗护理而住院。
在这个病例系列中，加巴喷丁暴露未引起或仅引起轻微毒性。
