Middleton Owen
Hennepin County Medical Examiner's Office, 530 Chicago Avenue, Minneapolis, MN 55415, USA.
J Forensic Sci. 2011 Sep;56(5):1373-5. doi: 10.1111/j.1556-4029.2011.01798.x. Epub 2011 May 6.
Gabapentin is an antiepileptic drug that is prescribed for both FDA-approved and multiple off-label conditions, and has a relatively safe side-effect profile. Rare cases of overdose-related adverse effects have been reported in the literature. Described herein are the circumstances and autopsy findings of a 62-year-old woman with a history of depression, whose death was caused by intentional ingestion of excess gabapentin. The postmortem peripheral blood gabapentin concentration as determined by high-performance liquid chromatography/tandem mass spectroscopy was 88 μg/mL. Previously reported cases of individuals surviving gabapentin overdoses are discussed and compared with this case. Based on a review of the available literature, this appears to be the first published report of a death due solely to gabapentin toxicity.
加巴喷丁是一种抗癫痫药物，被用于美国食品药品监督管理局（FDA）批准的适应症以及多种未获批准的情况，且其副作用相对安全。文献中报道过罕见的与过量用药相关的不良反应案例。本文描述了一名62岁有抑郁症病史女性的情况及尸检结果，其死亡系故意过量服用加巴喷丁所致。通过高效液相色谱/串联质谱法测定，死后外周血中加巴喷丁浓度为88μg/mL。文中讨论并比较了先前报道的加巴喷丁过量服用后存活的案例。基于对现有文献的回顾，这似乎是首篇仅因加巴喷丁毒性导致死亡的发表报告。
