莱纳斯·鲍林与镰状细胞病。
Linus Pauling and sickle cell disease.
作者信息
Eaton William A
机构信息
Laboratory of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA.
出版信息
Biophys Chem. 2003;100(1-3):109-16. doi: 10.1016/s0301-4622(02)00269-7.
The 1949 paper by Linus Pauling et al. [Science 110 (1949) 543-548] describing the discovery of sickle cell anemia as the first molecular disease had a major impact on biology and medicine. Inspired by the scholarly works of John Edsall on the history of hemoglobin research, I present a brief retrospective analysis of Pauling's paper. This is followed by some personal recollections of Edsall and Pauling.
莱纳斯·鲍林等人于1949年发表的论文[《科学》110 (1949) 543 - 548]描述了镰状细胞贫血作为首例分子疾病的发现，这篇论文对生物学和医学产生了重大影响。受约翰·埃德尔关于血红蛋白研究历史的学术著作启发，我对鲍林的论文进行简要的回顾性分析。随后是一些关于埃德尔和鲍林的个人回忆。
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