甲苯二异氰酸酯（TDI）-人血清白蛋白（HSA）偶联物特异性抗体在TDI诱导哮喘患者中的纵向研究。
Longitudinal study of specific antibodies to toluene diisocyanate (TDI)-human serum albumin (HSA) conjugate in patients with TDI-induced asthma.
作者信息
Park Hae Sim, Lee Soo Keol, Lee Young Mok, Kim Sun Sin, Nahm Dong Ho
机构信息
Department of Allergy & Rheumatology, Ajou University School of Medicine, Paldalgu, Wonchondong San-5, Suwon, Korea.
出版信息
Korean J Intern Med. 2002 Dec;17(4):249-51. doi: 10.3904/kjim.2002.17.4.249.
BACKGROUND
An appreciable number of patients with toluene diisocyanate (TDI)-induced asthma have high serum levels of specific IgE (sIgE) antibody to TDI-human serum albumin conjugate (HSA). A recent investigation suggested a role of specific IgG (sIgG) in the development of TDI asthma.
METHODS
We observed the changes in the levels of specific IgE and IgG antibodies to TDIHSA conjugate in TDI-induced asthmatic patients during seven years avoidance.
RESULTS
Six subjects with high sIgE and five with high sIgG were enrolled. All of them had taken anti-asthmatic medications with complete avoidance. Serum levels of sIgE and sIgG to TDI-HSA conjugate were detected by ELISA. The level of sIgE continued to decline up to 7 years and the mean half-life was 3.9 years. The mean half-life of sIgG was 4.5 yrs.
CONCLUSION
These findings suggest that both sIgE and sIgG to TDI-HSA conjugate may persist for several years after the last exposure to TDI.
背景
相当数量的甲苯二异氰酸酯（TDI）诱发哮喘患者血清中针对TDI - 人血清白蛋白偶联物（HSA）的特异性IgE（sIgE）抗体水平较高。最近的一项调查表明特异性IgG（sIgG）在TDI哮喘的发病过程中起作用。
方法
我们观察了TDI诱发的哮喘患者在避免接触TDI七年间针对TDI - HSA偶联物的特异性IgE和IgG抗体水平的变化。
结果
招募了6名高sIgE患者和5名高sIgG患者。他们都服用了抗哮喘药物并完全避免接触。通过酶联免疫吸附测定法（ELISA）检测血清中针对TDI - HSA偶联物的sIgE和sIgG水平。sIgE水平持续下降长达7年，平均半衰期为3.9年。sIgG的平均半衰期为4.5年。
结论
这些发现表明，针对TDI - HSA偶联物的sIgE和sIgG在最后一次接触TDI后可能会持续数年。
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