Street J, Downing J, Darke C
Welsh Transplantation and Immunology, Welsh Blood Service, Pontyclun, UK.
Eur J Immunogenet. 2003 Apr;30(2):129-31. doi: 10.1046/j.1365-2370.2003.00372.x.
The nucleotide sequence of exons 2 and 3 of B4408 has been confirmed. This allele has now been found in five, apparently unrelated, north-western European Caucasoid subjects, residing in Wales, on HLA haplotypes bearing: A0201, Cw0501 with DRB10401, DQA103, DQB10301 in four instances and DRB10701, DQA10201, DQB10202 in one instance. The unique serological reactivity of 'HLA-B44BO' was established using up to nine B4408 subjects and was easily identified using a variety of B44 and B62 antisera. The phenotype and gene frequencies of B*4408, in a sample of 40 473 subjects residing in Wales, were 0.01235% and 0.00006, respectively.
B4408外显子2和3的核苷酸序列已得到确认。现已在居住在威尔士的5名明显无亲缘关系的西北欧白种人受试者中发现了该等位基因，这些受试者的HLA单倍型分别为：4例带有A0201、Cw0501以及DRB10401、DQA103、DQB10301，1例带有DRB10701、DQA10201、DQB10202。利用多达9名B4408受试者确定了“HLA - B44BO”独特的血清学反应性，并且使用多种B44和B62抗血清很容易识别。在居住在威尔士的40473名受试者样本中，B*4408的表型频率和基因频率分别为0.01235%和0.00006。
