Tyson John J, Chen Katherine C, Novak Bela
Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Curr Opin Cell Biol. 2003 Apr;15(2):221-31. doi: 10.1016/s0955-0674(03)00017-6.
The physiological responses of cells to external and internal stimuli are governed by genes and proteins interacting in complex networks whose dynamical properties are impossible to understand by intuitive reasoning alone. Recent advances by theoretical biologists have demonstrated that molecular regulatory networks can be accurately modeled in mathematical terms. These models shed light on the design principles of biological control systems and make predictions that have been verified experimentally.
细胞对外部和内部刺激的生理反应由基因和蛋白质在复杂网络中相互作用所支配，这些网络的动力学特性仅凭直观推理是无法理解的。理论生物学家最近的进展表明，分子调控网络可以用数学术语精确建模。这些模型揭示了生物控制系统的设计原则，并做出了已通过实验验证的预测。
