Bradley G W, Henderson A K, Mills R J
Postgrad Med J. 1976 Mar;52(605):151-3. doi: 10.1136/pgmj.52.605.151.
The effects of propranolol and salbutamol on conventional pulmonary function tests and closing volume have been studied in ten normal subjects. Propranolol and salbutamol had minor effects on measurements of airways resistance but had no effect on closing volume which is particularly sensitive to changes in peripheral airways. It was concluded that propranolol had negligible overall effect on central and peripheral airways properties in normal subjects, and it would appear that β-adrenergic activity has little measurable influence on peripheral airways in normal man at rest.
已在10名正常受试者中研究了普萘洛尔和沙丁胺醇对传统肺功能测试及闭合气量的影响。普萘洛尔和沙丁胺醇对气道阻力测量有轻微影响，但对闭合气量无影响，而闭合气量对周边气道变化特别敏感。得出的结论是，普萘洛尔对正常受试者的中央和周边气道特性的总体影响可忽略不计，而且似乎在静息状态下，β-肾上腺素能活性对正常男性的周边气道几乎没有可测量的影响。
