Gayrard P, Orehek J, Charpin J
Respiration. 1975;32(4):294-304. doi: 10.1159/000193658.
Patients with asthma, exhibiting spontaneous bronchial obstruction, from mild to medium severity, were examined by body plethysmography. Results were expressed as specific airway resistance (SRaw) in preference to specific conductance, the latter leading to errors, in particular in cases with dissimilar baseline values. After the inhalation of a beta-stimulating drug (salbutamol), the decreases in SRaw was directly related to initial SRaw, either in a group (n equal 30) or in individual cases. After the injection of a beta-blocking drug (propranolol), the increase in SRaw, found abnormal in 60% of the subjects, could be related to initial SRaw neither in a group (n equal 40) nor in individual cases. These findings indicate that submaximal bronchial obstruction in patients with asthma is mainly due to a bronchoconstriction, whatever the degree of the obstruction may be. On the opposite, there is an increased bronchodilator adrenergic influence in a majority of patients, not predictable after the degree of initial airway obstruction.
对患有哮喘且表现出自发性支气管阻塞（轻度至中度）的患者进行了体容积描记法检查。结果以比气道阻力（SRaw）表示，而非比传导率，因为后者会导致误差，尤其是在基线值不同的情况下。吸入β受体激动剂（沙丁胺醇）后，无论是在一组（n = 30）还是在个体病例中，SRaw的降低都与初始SRaw直接相关。注射β受体阻滞剂（普萘洛尔）后，在60%的受试者中发现SRaw升高，这在一组（n = 40）或个体病例中均与初始SRaw无关。这些发现表明，哮喘患者的次最大支气管阻塞主要是由于支气管收缩，无论阻塞程度如何。相反，大多数患者存在增强的支气管扩张肾上腺素能影响，这在初始气道阻塞程度之后无法预测。
