Nomura J, Arase Y, Sugaya S, Moriya T, Chen Z, Takahashi S, Kita K, Kikuno K, Nomura F, Suzuki N
Department of Environmental Biochemistry, Chiba University, Chiba, Japan.
J Gravit Physiol. 2001 Jul;8(1):P125-6.
It is important to clarify the molecular mechanisms of physiological responses of the human body to changes in gravity. Previous reports demonstrated that gravity-changing stress increases the human urinary concentration of 8-hydroxy-2'-deoxyguanosine (8-OHdG). However, it has yet to be clarified whether repetitive parabolic flight modulates the urinary concentration of 8-OHdG after exposure to gravity-changing stress. In the present study, the effects of the number of previous experiences with parabolic flight on urinary excretion of 8-OHdG and concentration of serum ACTH were examined in 12 healthy volunteers.
阐明人体对重力变化的生理反应的分子机制很重要。先前的报告表明，重力变化应激会增加人体尿液中8-羟基-2'-脱氧鸟苷（8-OHdG）的浓度。然而，反复进行抛物线飞行是否会在暴露于重力变化应激后调节8-OHdG的尿液浓度，目前尚不清楚。在本研究中，对12名健康志愿者进行了研究，考察了先前抛物线飞行经历的次数对8-OHdG尿液排泄和血清促肾上腺皮质激素（ACTH）浓度的影响。
