Box Gloria G, Lindsey Ronald W, Curylo Lukas, Miclau Theodore, Alexander Jerry W, Perren Stephan M
Department of Orthopedic Surgery, Baylor College of Medicine, Houston, Tex 77030, USA.
Orthopedics. 2003 Mar;26(3):311-5. doi: 10.3928/0147-7447-20030301-11.
Bone grafting of osseous defects is often delayed to minimize the risk of infection, however, the effect of this delay on defect healing is not clear. Unilateral oblong unicortical diaphyseal femoral defects (30 x 4.5 mm) were created in 3 groups of 18 adult canines that were grafted with autogenous bone immediately, at 2 weeks, and at 6 weeks. After an 8-week healing period, paired femurs, h consisted of defect versus intact specimens, were assessed by biomechanical testing and microradiography. No differences were demonstrated biomechanically or radiographically between the healing defects with immediate versus delayed bone grafting. This study suggests that within the first 6 weeks postoperatively osseous defects can be grafted with autologous bone without adversely affecting bone graft incorporation.
骨缺损的骨移植通常会延迟进行，以将感染风险降至最低，然而，这种延迟对缺损愈合的影响尚不清楚。在三组共18只成年犬中制造了单侧长方形单皮质骨干股骨缺损（30×4.5毫米），分别立即、在2周和6周时用自体骨进行移植。经过8周的愈合期后，通过生物力学测试和显微放射ography对由缺损与完整标本组成的配对股骨进行评估。立即与延迟骨移植的愈合缺损在生物力学或放射学上均未显示出差异。本研究表明，术后前6周内，骨缺损可用自体骨移植，而不会对骨移植融合产生不利影响。 （注：原文中“microradiography”翻译为“显微放射ography”，这里的“radiography”可能是特定领域的专业术语，具体准确翻译可能需要结合更多背景知识，这里暂保留英文形式。）
