Morris M, McCann S M, Orias R
Proc Soc Exp Biol Med. 1976 May;152(1):95-8. doi: 10.3181/00379727-152-39336.
To examine if hypothalamic or pituitary hormones are involved in the induction of the natriuresis which follows the injection of hypertonic saline or norepinephrine into the third ventricle, lesions were placed in the median eminence and the responses to intraventricular norepinephrine or hypertonic saline were evaluated. Sham lesions in which the electrode was lowered into the brain but stopped short of the hypothalamic region did not interfere with the natriuresis, kaliuresis, and antidiuresis induced by the third ventricular injection of either hypertonic sodium chloride or norepinephrine. Lesions in the median eminence which induced diabetes insipidus as evidenced by an increase in water consumption to approximately four times normal completely abolished the natriuresis and kaliuresis in response to intraventricular hypertonic saline or norepinephrine and diminished the antidiuresis. The observations suggest the possibility that a natriuretic hormone(s) is involved in the induction of central natriuresis.
为了研究下丘脑或垂体激素是否参与了向第三脑室内注射高渗盐水或去甲肾上腺素后所诱导的利钠作用，研究人员在正中隆起处制造损伤，并评估对脑室内注射去甲肾上腺素或高渗盐水的反应。假损伤组中，电极插入脑内但未到达下丘脑区域，此操作并未干扰第三脑室内注射高渗氯化钠或去甲肾上腺素所诱导的利钠、利尿和抗利尿作用。正中隆起处的损伤导致尿崩症，表现为饮水量增加至正常水平的约四倍，这完全消除了对脑室内高渗盐水或去甲肾上腺素的利钠和利尿反应，并减弱了抗利尿作用。这些观察结果提示，可能有一种利钠激素参与了中枢性利钠作用的诱导过程。
