Li Allen G, Koster Maranke I, Wang Xiao Jing
Department of Dermatology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Cytokine Growth Factor Rev. 2003 Apr;14(2):99-111. doi: 10.1016/s1359-6101(03)00005-4.
The transforming growth factor beta (TGFbeta) superfamily encompasses a number of structurally related proteins that can be divided into several subfamilies including TGFbetas, activins/inhibins and bone morphogenetic proteins (BMPs). The Smads are major intracellular mediators in transducing the signals of TGFbeta superfamily members, and are abundantly expressed in the developing epidermis and epidermal appendages. Moreover, the phenotypes of transgenic/knockout mice with altered components of the TGFbeta superfamily signaling pathway suggest that TGFbeta superfamily signaling is required for epidermal/appendage development. TGFbeta superfamily members are involved in most events during epidermal/appendage development through the TGFbeta signal transduction pathway and through cross talk with other signaling pathways. Future studies will be instrumental in defining the precise roles for TGFbeta superfamily signaling in epidermal/appendage development.
转化生长因子β（TGFβ）超家族包含许多结构相关的蛋白质，这些蛋白质可分为几个亚家族，包括TGFβ、激活素/抑制素和骨形态发生蛋白（BMP）。Smads是转导TGFβ超家族成员信号的主要细胞内介质，在发育中的表皮和表皮附属器中大量表达。此外，TGFβ超家族信号通路成分改变的转基因/基因敲除小鼠的表型表明，TGFβ超家族信号对于表皮/附属器发育是必需的。TGFβ超家族成员通过TGFβ信号转导途径以及与其他信号通路的相互作用，参与表皮/附属器发育过程中的大多数事件。未来的研究将有助于确定TGFβ超家族信号在表皮/附属器发育中的精确作用。
