Key Laboratory of Animal Genetics and Breeding on the Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.
Sheep Breeding Engineering Technology Research Center, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.
Int J Mol Sci. 2024 Jan 2;25(1):584. doi: 10.3390/ijms25010584.
The Ordos fine-wool sheep is a high-quality breed in China that produces superior natural textiles and raw materials such as wool and lamb meat. However, compared to the Australian Merino sheep, there is still a gap in terms of the wool fiber fineness and wool yield. The hair follicle is the main organ that controls the type of wool fiber, and the morphological changes in the secondary hair follicle are crucial in determining wool quality. However, the process and molecular mechanisms of hair follicle morphogenesis in Ordos fine-wool sheep are not yet clear. Therefore, analyzing the molecular mechanisms underlying the process of follicle formation is of great significance for improving the fiber diameter and wool production of Ordos fine-wool sheep. The differential expressed genes, , , , and , which related to primary hair follicles and secondary hair follicles, were extracted from the dermal papillae. Based on pseudo-time analysis, the differentiation trajectories of dermal lineage cells and epidermal lineage cells in the Ordos fine-wool sheep were successfully constructed, providing a theoretical basis for breeding research in Ordos fine-wool sheep.
鄂尔多斯细毛羊是中国优质的绵羊品种，可产出优质的天然纺织品以及羊毛和羊肉等原材料。然而，与澳大利亚美利奴羊相比，鄂尔多斯细毛羊的羊毛纤维细度和产毛量仍存在一定差距。毛囊是控制羊毛纤维类型的主要器官，次级毛囊的形态变化对羊毛品质的决定至关重要。但是，鄂尔多斯细毛羊毛囊形态发生的过程和分子机制尚不清楚。因此，分析毛囊形成过程中的分子机制对于提高鄂尔多斯细毛羊的纤维直径和产毛量具有重要意义。从真皮乳头中提取出与初级毛囊和次级毛囊相关的差异表达基因、、、、和。基于伪时间分析，成功构建了鄂尔多斯细毛羊真皮谱系细胞和表皮谱系细胞的分化轨迹，为鄂尔多斯细毛羊的选育研究提供了理论基础。
