2型糖尿病中的事件相关电位P300
Event-related potentials P300 in type 2 diabetes mellitus.
作者信息
Chen Xuan, Chen Wei, Chen Shen-ren, Luo Yi-ping
机构信息
Department of Neurology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, Chin.
出版信息
Di Yi Jun Yi Da Xue Xue Bao. 2003 Mar;23(3):257-9.
OBJECTIVE
To investigate event-related potentials (ERP) P(300) in patients with type 2 diabetes mellitus (DM) for early detection of the abnormalities in cognitive function and studying the related factors.
METHODS
With the assistance of Nicolet Vinking IV equipment, ERP (P(300)) were tested in 30 type 2 diabetic patients and 30 healthy subjects matched for age, gender, and education background, and the the results were analyzed statistically. The relationships of each ERP parameter with glucose hemoglobin (GHb) and blood lipid levels and renal function were analyzed.
RESULTS
No significant difference was found in P(300) latencies in the control group irrespective of the gender and education (P > 0.05), while the latencies were significantly prolonged (P < 0.01) and the amplitudes decreased (P < 0.05) in diabetic patients. It was found that P(300) correlated with glucose hemoglobin (GHb) and blood lipid levels (P < 0.05).
CONCLUSION
ERP test is useful for early detection of cognition dysfunction in DM cases, helping to timely identify diabetic patients with potential dementia.
目的
研究2型糖尿病（DM）患者的事件相关电位（ERP）P（300），以早期发现认知功能异常并探讨相关因素。
方法
借助Nicolet Vinking IV设备，对30例2型糖尿病患者及30例年龄、性别、教育背景相匹配的健康受试者进行ERP（P（300））检测，并对结果进行统计学分析。分析各ERP参数与糖化血红蛋白（GHb）、血脂水平及肾功能的关系。
结果
对照组P（300）潜伏期在性别和教育程度方面无显著差异（P>0.05），而糖尿病患者的潜伏期显著延长（P<0.01），波幅降低（P<0.05）。发现P（300）与糖化血红蛋白（GHb）及血脂水平相关（P<0.05）。
结论
ERP检测有助于早期发现DM患者的认知功能障碍，有助于及时识别有潜在痴呆风险的糖尿病患者。
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