Zhou Juan, Zhang Min, Li Xiao-min
Faculty of Traditional Chinese Medicine, First Military Medical University, Guangzhou 510515.
Di Yi Jun Yi Da Xue Xue Bao. 2003 Mar;23(3):262-4.
To investigate the differences of serum lipids and serum lipoprotein spectrum between patients with cerebral hemorrhage (CH) and cerebral infarction (CI), and study their features of expression in the 2 cerebral conditions.
Serum levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), very-low-density lipoprotein cholesterol (vLDLC), low-density lipoprotein cholesterol (LDLC) and serum lipoprotein electrophoretogram were determined in 59 CI and 21 CH patients as well as in 30 normal subjects.
CI patients had higher levels of TC, LDLC, alpha-lipoprotein (alpha LP), beta-lipoprotein (beta LP) and intermediate-density beta-lipoprotein (int beta LP) than the normal subjects, and the CH patients had lower LDLC level than the CI patients. The CH patients had also higher levels of beta LP, int beta LP and LDLC than the normal subjects. Progressive regression analysis was performed and resulted in the selection of beta LP, int beta LP and HDLC as the best discriminators for cerebral vascular diseases, which were valid in classifying 71.3% of the cases included in this study.
beta LP, int beta LP and HDLC are important clinical indicators to predict cerebral vascular diseases.
探讨脑出血（CH）患者与脑梗死（CI）患者血脂及血清脂蛋白谱的差异，研究其在这两种脑部疾病中的表达特征。
测定59例CI患者、21例CH患者及30例正常受试者的血清甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDLC）、极低密度脂蛋白胆固醇（vLDLC）、低密度脂蛋白胆固醇（LDLC）水平及血清脂蛋白电泳图。
CI患者的TC、LDLC、α-脂蛋白（αLP）、β-脂蛋白（βLP）及中密度β-脂蛋白（intβLP）水平高于正常受试者，CH患者的LDLC水平低于CI患者。CH患者的βLP、intβLP及LDLC水平也高于正常受试者。进行逐步回归分析，结果选择βLP、intβLP及HDLC作为脑血管疾病的最佳判别指标，对本研究纳入的71.3%的病例分类有效。
βLP、intβLP及HDLC是预测脑血管疾病的重要临床指标。
