Yin Jia, Wang Xin-yu, Zhang Min
Department of Neurology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Di Yi Jun Yi Da Xue Xue Bao. 2003 Aug;23(8):844-6.
To investigate the changes in the levels of serum cholesterol and high-density lipoprotein and in serum lipoprotein electrophoretogram in elderly patients with cerebral infarction.
Serum lipoprotein electrophoretograms (SLPG) of 118 elderly patients with cerebral infarction and 60 healthy elderly subjects were measured by means of double gradient polyacrylamide gel electrophoresis, and the serum concentrations of total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were determined by enzymatic method.
Compared with the control group, the serum level of HDL-C was significantly increased in the patients (1.0+/-0.3 mmol/L), who also had decreased TC/HDL-C ratio (5.3+/-1.4), but no significant difference occurred in terms of TC concentration between these two groups. Among the patients with cerebral infarction, 86.4% had abnormalities of SLPG, especially in the alpha-lipoprotein electrophoretogram (P<0.001-0.05) regardless of HDL-C elevations.
Decreased HDL-C, elevated TC/HDL-C ratio and abnormal SLPG may be the risk factors for the onset of cerebral infarction in senior patients, for which alpha-lipoprotein electrophoretogram can be more sensitive than serum HDL-C level. TC levels is of little value in predicting cerebral infarction.
探讨老年脑梗死患者血清胆固醇、高密度脂蛋白水平及血清脂蛋白电泳图的变化。
采用双梯度聚丙烯酰胺凝胶电泳法检测118例老年脑梗死患者和60例健康老年受试者的血清脂蛋白电泳图（SLPG），并采用酶法测定血清总胆固醇（TC）和高密度脂蛋白胆固醇（HDL-C）浓度。
与对照组相比，患者血清HDL-C水平显著升高（1.0±0.3 mmol/L），TC/HDL-C比值降低（5.3±1.4），但两组间TC浓度无显著差异。在脑梗死患者中，86.4%的患者SLPG异常，尤其是α-脂蛋白电泳图异常（P<0.001-0.05），且与HDL-C升高无关。
HDL-C降低、TC/HDL-C比值升高及SLPG异常可能是老年患者脑梗死发病的危险因素，其中α-脂蛋白电泳图比血清HDL-C水平更敏感。TC水平对预测脑梗死价值不大。
