Alonso David, Radomski Marek W
Department of Integrative Biology and Pharmacology, University of Texas-Houston, 77030, USA.
Heart Fail Rev. 2003 Jan;8(1):47-54. doi: 10.1023/a:1022194921040.
Platelets play an important role in physiologic hemostasis and pathologic thrombosis that complicate the course of vascular disorders. A number of platelet functions including adhesion, aggregation and recruitment are controlled by nitric oxide (NO) generated by platelets and the endothelial cells. Derangements in this generation may contribute to the pathogenesis of thrombotic complications of vascular disorders. The pharmacologic supplementation of the diseased vasculature with drugs releasing NO may help to restore the hemostatic balance.
血小板在生理止血和使血管疾病病程复杂化的病理性血栓形成中发挥重要作用。包括黏附、聚集和募集在内的多种血小板功能受血小板和内皮细胞产生的一氧化氮（NO）调控。这一生成过程的紊乱可能促成血管疾病血栓性并发症的发病机制。用释放NO的药物对病变血管进行药理学补充可能有助于恢复止血平衡。
