印度缺血性心脏病患者血小板氧化应激。
Platelets oxidative stress in Indian patients with ischemic heart disease.
机构信息
Department of Clinical Laboratory and Nutritional Sciences, University of Massachusetts Lowell, Massacchusetts 01854, USA.
出版信息
J Clin Lab Anal. 2010;24(1):49-54. doi: 10.1002/jcla.20363.
BACKGROUND
Oxidative stress has been implicated in the development of atherosclerosis and vascular tissue injury. Both platelet activation and lipid peroxidation are known to play major role in ischemic heart disease. The purpose of this study was to investigate the status of platelets oxidative stress in Indian patients with ischemic heart disease.
METHODS
We measured platelets aggregation, malonyldialdehyde (MDA), plasma-ionized Ca2+, and antioxidant enzymes, i.e., glutathione peroxidase and superoxide dismutase in healthy volunteers and patients with myocardial infarction, unstable and stable angina 40 subjects each.
RESULTS
Platelets aggregation, MDA, and plasma-ionized Ca(2+) have increased significantly across the patients groups compared with controls, this increase was accompanied by an overall decrease in the antioxidant enzymes activity; except for the slight increases in the glutathione peroxidase levels among the myocardial infarction patients.
CONCLUSIONS
The current results suggest that platelet lipid peroxidation as marked by increased MDA level is augmented in ischemic heart diseases. The increased oxidative stress seen in these patients was accompanied by platelet activation and impaired antioxidant enzymes activity.
背景
氧化应激与动脉粥样硬化和血管组织损伤的发展有关。血小板活化和脂质过氧化都被认为在缺血性心脏病中起主要作用。本研究的目的是探讨印度缺血性心脏病患者血小板氧化应激的状况。
方法
我们测量了 40 名健康志愿者和心肌梗死、不稳定型和稳定型心绞痛患者的血小板聚集、丙二醛（MDA）、血浆离子钙（Ca2+）和抗氧化酶，如谷胱甘肽过氧化物酶和超氧化物歧化酶。
结果
与对照组相比，血小板聚集、MDA 和血浆离子钙在所有患者组中均显著增加，这种增加伴随着抗氧化酶活性的整体下降；除心肌梗死患者的谷胱甘肽过氧化物酶水平略有增加外。
结论
目前的结果表明，血小板脂质过氧化（以 MDA 水平升高为标志）在缺血性心脏病中增加。这些患者中观察到的氧化应激增加伴随着血小板活化和抗氧化酶活性受损。
Zotero 插件