吲哚美辛和前列腺素E1对兔耳动脉对神经刺激的血管收缩反应的影响。

Effects of indomethacin and PGE1 on the vasoconstrictor responses of the rabbit ear artery to nerve stimulation.

作者信息

Hadházy P, Nádor T

出版信息

Prostaglandins. 1976 Feb;11(2):241-50. doi: 10.1016/0090-6980(76)90147-7.

Abstract

Actions of PGE1 and indomethacin on electrically induced vasoconstriction in isolated ear arteries of rabbits were studied. PGE1 (8.5 X 10(-9) M) reduced the vasoconstriction; this inhibition was inversely related to the rate of stimulation. Indomethacin (1.5 X 10(-6) M) potentiated the constrictor responses to nerve stimulation. The degree of this potentiation was also frequency-dependent being greater at low (1 - 2 HZ) than at high (8 - 16 HZ) rate of stimulation. These findings support the view that prostaglandins, in addition to their action on vascular smooth muscle cells, play a functional role in the regulation of tone of the rabbit ear artery by a negative feed-back control of adrenergic neurotransmission.

摘要

研究了前列腺素E1（PGE1）和吲哚美辛对兔离体耳动脉电诱导血管收缩的作用。PGE1（8.5×10⁻⁹ M）可减轻血管收缩；这种抑制作用与刺激速率呈负相关。吲哚美辛（1.5×10⁻⁶ M）增强了对神经刺激的收缩反应。这种增强的程度也与频率有关，在低刺激频率（1 - 2赫兹）时比高刺激频率（8 - 16赫兹）时更大。这些发现支持了这样一种观点，即前列腺素除了对血管平滑肌细胞有作用外，还通过对肾上腺素能神经传递的负反馈控制，在调节兔耳动脉张力中发挥功能性作用。