钙离子对前列腺素E1抑制兔耳动脉电诱导血管收缩作用的拮抗作用。
Antagonism by Ca2+ of the inhibitory action of PGE1 on the electrically induced vasoconstriction in the rabbit ear artery.
作者信息
Hadházy P, Todorov S, Nádor T
出版信息
Eur J Pharmacol. 1975 Dec;34(2):393-5. doi: 10.1016/0014-2999(75)90270-8.
PMID:186274
Abstract
The inhibitory action of PGE1 on vasoconstrictor responses to nerve stimulation of isolated ear arteries of rabbits was studied in the presence of 1.0 to 7.5 mM external calcium concentration. Raising the [Ca]0 in the medium increased the electrically induced vasoconstriction and antagonized the inhibitory effect of PGE1 on constrictor responses. This antagonism is probably due to an interaction between Ca2+ and PGE1 in the sympathetic nerves to the vessel.
摘要
在外部钙浓度为1.0至7.5 mM的情况下，研究了前列腺素E1（PGE1）对兔离体耳动脉神经刺激引起的血管收缩反应的抑制作用。提高培养基中的[Ca]0可增强电诱导的血管收缩，并拮抗PGE1对收缩反应的抑制作用。这种拮抗作用可能是由于Ca2+与血管交感神经中的PGE1之间的相互作用所致。
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