前列腺素E1对平滑肌收缩和钙反应的抑制作用。

Inhibitory action of prostaglandin E1 on smooth muscle contraction and calcium responses.

作者信息

Michibayashi T

出版信息

Prostaglandins. 1978 May;15(5):803-12. doi: 10.1016/0090-6980(78)90146-6.

Abstract

The relation between the inhibitory action of prostaglandin (E1 (PGE1) and external Ca concentration was investigated using the guinea-pig isolated ureter and the perfused central artery of the rabbit isolated ear. PGE1 20 ng/ml reduced the ureteral contraction evoked by a single electrical stimulation. This inhibitory action of PGE1 was enhanced with a decreased external Ca concentration. PGE1 100 ng/ml also reduced Ca-induced contracture of the ureter depolarized in Ca-free K(80 mM)-Krebs' solution. Furthermore, PGE1 50 ng/ml inhibited the responses of peripheral vascular resistance to noradrenaline, and this effect increased with a reduced external Ca concentration.

摘要

使用豚鼠离体输尿管和兔离体耳灌注中央动脉，研究了前列腺素（E1（PGE1））的抑制作用与细胞外钙浓度之间的关系。20 ng/ml的PGE1可降低单次电刺激诱发的输尿管收缩。随着细胞外钙浓度降低，PGE1的这种抑制作用增强。100 ng/ml的PGE1也可降低在无钙K（80 mM）- Krebs溶液中去极化的输尿管的钙诱导挛缩。此外，50 ng/ml的PGE1可抑制外周血管阻力对去甲肾上腺素的反应，且随着细胞外钙浓度降低，这种作用增强。