Ragab M I, Edelman D A
Prostaglandins. 1976 Feb;11(2):261-73.
The relative safety and effectiveness of vacuum aspiration and the intrauterine administration of 5 mg PGF2alpha for terminating pregnancies within two weeks of a missed menstrual period were evaluated in a study where subjects were randomly assigned to procedures; 100 patients were aborted with vacuum aspiration and 100 patients were aborted with PGF2alpha. All PGF2alpha-treated patients were premedicated with meperidine, diazepam and atropine. Complications were infrequent with either of the procedures. Vomiting occurred more frequently during the PGF procedure (30.0%) than during the vaccum aspiration procedure (9.0%). The intrauterine instillation of PGF2alpha successfully terminated all pregnancies. One patient continued to be pregnant after the vacuum aspiration procedure. Based on the results of this study both study procedures appeared to be safe and effective for terminating early first trimester pregnancies.
在一项研究中，评估了负压吸宫术和宫腔内注射5毫克前列腺素F2α用于终止月经推迟两周内妊娠的相对安全性和有效性，研究中受试者被随机分配接受不同手术；100例患者接受负压吸宫术流产，100例患者接受前列腺素F2α流产。所有接受前列腺素F2α治疗的患者均预先使用哌替啶、地西泮和阿托品进行预处理。两种手术的并发症都不常见。前列腺素手术期间呕吐发生率（30.0%）高于负压吸宫术期间（9.0%）。宫腔内注射前列腺素F2α成功终止了所有妊娠。1例患者在负压吸宫术后仍继续妊娠。基于本研究结果，两种手术方法在终止孕早期妊娠方面似乎都是安全有效的。
