孕中期流产：羊膜腔内前列腺素F2α与高渗盐水的比较

Midtrimester abortion: a comparison of intraamniotic prostaglandin F2alpha and hypertonic saline.

作者信息

Ragab M I, Edelman D A

出版信息

Int J Gynaecol Obstet. 1976;14(5):393-6. doi: 10.1002/j.1879-3479.1976.tb00072.x.

DOI:10.1002/j.1879-3479.1976.tb00072.x

Abstract

The safety and effectiveness of two intraamniotic prostaglandin F2alpha (PGF2alpha) dose schedules (a single 50 mg dose and a repeated 25 mg dose) and intraamniotic hypertonic saline were evaluated in a study where each abortion procedure was randomly assigned to 50 patients. All patients were at 16 to 20 weeks' gestation. Rates of gastrointestinal and other side effects were generally higher for the 50 mg PGF2alpha dose schedule than for the other two procedures. The repeated 25 mg PGF2alpha dose schedule resulted in higher 24-hour (68.0%) and 48-hour (98.0%) cumulative abortion rates than the 50 mg PGF2alpha dose schedule (54.0%, 92.0%) or saline (34.7%, 91.8%). Rates of spontaneous placental expulsion were highest for the repeated 25 mg PGF2alpha dose (74.0%) and lowest for the 50 mg PGF2alpha dose schedule (40.0%).

摘要

在一项研究中，对两种羊膜腔内前列腺素F2α（PGF2α）给药方案（单次50毫克剂量和重复25毫克剂量）以及羊膜腔内高渗盐水的安全性和有效性进行了评估，该研究中每个流产手术随机分配给50名患者。所有患者均处于妊娠16至20周。50毫克PGF2α给药方案的胃肠道及其他副作用发生率通常高于其他两种手术。重复25毫克PGF2α给药方案导致的24小时（68.0%）和48小时（98.0%）累积流产率高于50毫克PGF2α给药方案（54.0%，92.0%）或盐水（34.7%，91.8%）。重复25毫克PGF2α剂量的自然胎盘排出率最高（74.0%），50毫克PGF2α给药方案最低（40.0%）。