Aksenova V A, Luginova E F
Probl Tuberk. 2003(1):25-8.
The paper presents the results of a follow-up of children and adolescents who isolate drug-resistant Mycobacterium tuberculosis (MBT) strains of those with manifestations of tuberculosis and preserved sensitivity to antibacterial agents. Bacterial isolation in children and adolescents is scanty and multiple. There is a high rate of resistance to isoniazid, streptomycin, and rifampicin. The vast majority of children and adolescents who isolate drug-resistant MBT strains have been found to contact a patient who also isolate drug-resistant MBT. The drug sensitivity of MBT in patients is identical to that of sources of their contamination. Most patients with drug-resistant tuberculosis have been ascertained as having been registered in dispensaries and treated with drugs, which suggests that the use of chemotherapy in prophylactic doses, particularly in patients contacting a bacterial isolator, does not prevent local tuberculosis.
本文介绍了对儿童和青少年进行随访的结果，这些儿童和青少年分离出对结核病有临床表现且对抗菌药物仍敏感的耐多药结核分枝杆菌（MBT）菌株。儿童和青少年中的细菌分离数量少且多样。对异烟肼、链霉素和利福平的耐药率很高。已发现绝大多数分离出耐多药MBT菌株的儿童和青少年与同样分离出耐多药MBT的患者有接触。患者中MBT的药敏性与其污染源的药敏性相同。大多数耐多药结核病患者已被确定在药房登记并接受过药物治疗，这表明使用预防剂量的化疗，特别是在接触细菌隔离者的患者中，不能预防局部结核病。
