Vasil'eva I A, Andreevskaia S N, Smirnova T G, Chernousova L I, Chukanov V I
Probl Tuberk Bolezn Legk. 2004(8):25-8.
Two hundred and twenty-four patients with pulmonary tuberculosis and bacterial isolation were examined to study the efficiency of chemotherapy in patients who isolated drug-resistant strains of Mycobacterium tuberculosis (MBT) of different genotypes. According to the pattern of susceptibility to antituberculous drugs (ATDs), the patients were divided into 3 groups: 1) those who were found to have ATD-susceptible MBT; 2) those who had multiresistant MBT susceptible to all ATDs, other than isoniazid and rifampicin; 3) those with multidrug resistance. MBT genotyping in accordance with the polymorphism of the length of restriction fragments IS6110 has indicated that the strains of the families W and AI were prevalent in all the groups. However, the strains of mycobacteria of the W family were most frequently (62%) detected among the patients with tuberculosis with slight drug resistance. Treatment was performed in accordance with the data of tests of MBT for their susceptibility to chemical agents. Comparison of the efficiency of therapy failed to reveal any relationship of the genotype of the causative agent within the groups of patients with tuberculosis with different resistance of Mycobacteria, including those with slight drug resistance. At the same time, the pattern of drug susceptibility of MBT largely determined the frequency and trends of bacterial isolation cessation.
对224例肺结核且有细菌分离结果的患者进行了检查，以研究化疗对分离出不同基因型结核分枝杆菌（MBT）耐药菌株患者的疗效。根据对抗结核药物（ATD）的敏感模式，将患者分为3组：1）那些被发现具有对ATD敏感的MBT的患者；2）那些具有对除异烟肼和利福平之外的所有ATD敏感的多重耐药MBT的患者；3）那些具有耐多药的患者。根据限制片段IS6110长度的多态性进行的MBT基因分型表明，W家族和AI家族的菌株在所有组中均占主导地位。然而，在耐药性轻微的肺结核患者中，W家族分枝杆菌菌株的检出频率最高（62%）。治疗是根据MBT对化学药物敏感性测试的数据进行的。对治疗效果的比较未能揭示在具有不同分枝杆菌耐药性（包括耐药性轻微的患者）的肺结核患者组中病原体基因型之间的任何关联。与此同时，MBT的药敏模式在很大程度上决定了细菌分离停止的频率和趋势。
