Sahoo Sunati, Ryan Christopher W, Recant Wendy M, Yang Ximing J
Department of Pathology, Section of Hematology and Oncology, The University of Chicago, Chicago, IL, USA.
Arch Pathol Lab Med. 2003 Mar;127(3):360-3. doi: 10.5858/2003-127-0360-AMAECI.
Sarcoma can arise within a germ cell tumor (GCT) from a malignant transformation of teratomatous elements or as late sequelae to radiation therapy. Angiosarcoma as a malignant component in testicular GCTs has rarely been reported and is often misdiagnosed as embryonal carcinoma. We report the case of a 23-year-old man with mature teratoma of the testis and retroperitoneal metastasis exhibiting components of mature teratoma intermingled with high-grade angiosarcoma. It is important to recognize the presence of a high-grade sarcomatous component within a GCT because of its aggressive clinical behavior and different response to therapy.
肉瘤可发生于生殖细胞肿瘤（GCT）内，由畸胎瘤成分的恶性转化引起，或作为放射治疗的晚期后遗症出现。血管肉瘤作为睾丸GCT的恶性成分鲜有报道，且常被误诊为胚胎性癌。我们报告了一例23岁男性病例，其睾丸成熟畸胎瘤伴腹膜后转移，肿瘤表现为成熟畸胎瘤成分与高级别血管肉瘤相互混杂。认识到GCT内存在高级别肉瘤成分很重要，因为其临床行为具有侵袭性，且对治疗的反应不同。
