Copcu E, Aktas A, Sişman N, Oztan Y
Plastic and Reconstructive Surgery Department, Medical Faculty, Adnan Menderes University, Aydin, Turkey.
Clin Exp Dermatol. 2003 Mar;28(2):138-41. doi: 10.1046/j.1365-2230.2003.01210.x.
Marjolin's ulcer is a rare and often aggressive cutaneous malignancy that arises in previously traumatized or chronically inflamed skin, particularly after burns. We reviewed 264 burns cases treated in our departments to assess the frequency and clinicopathological features of this malignant complication. We found 31 cases of Marjolin's ulcer and a further 14 cases of nonmalignant ulceration at previous burn sites. Eighteen Marjolin's ulcers were located on the extremities, six on the scalp, six on the trunk, and one on the nose. Most malignancies were squamous cell carcinomas. The average time lag between the burns and subsequent malignant ulceration was 19 years. Four of the malignant ulcers had spread to regional lymph nodes, but there were no distant metastases. This study emphasizes that Marjolin's ulcer should be considered as a significant postburn complication.
马乔林溃疡是一种罕见且通常具有侵袭性的皮肤恶性肿瘤，发生于先前受过创伤或长期发炎的皮肤，尤其是烧伤后。我们回顾了在我们科室治疗的264例烧伤病例，以评估这种恶性并发症的发生率和临床病理特征。我们发现了31例马乔林溃疡病例，以及另外14例先前烧伤部位的非恶性溃疡病例。18例马乔林溃疡位于四肢，6例位于头皮，6例位于躯干，1例位于鼻子。大多数恶性肿瘤为鳞状细胞癌。烧伤与随后发生恶性溃疡之间的平均时间间隔为19年。4例恶性溃疡已扩散至区域淋巴结，但无远处转移。这项研究强调，马乔林溃疡应被视为一种重要的烧伤后并发症。
